Small-cell undifferentiated (neuroendocrine) carcinoma of the cecum in a child with common variable immunodeficiency

Am J Pediatr Hematol Oncol. 1993 May;15(2):258-61. doi: 10.1097/00043426-199305000-00016.

Abstract

Purpose: Patients with primary or secondary immunodeficiencies are known to be at increased risk for the development of malignancies, predominantly of lymphoreticular origin.

Patients and methods: We here describe a patient with infant-onset hypogammaglobulinemia due to a common variable immunodeficiency. At the age of 16 a small-cell undifferentiated (neuroendocrine) carcinoma of the cecum (SCUNC) was diagnosed.

Results: Neurohormonal analysis showed normal values.

Conclusions: To our knowledge this is the first report in childhood of SCUNC of the gastrointestinal tract, which has also previously not been associated with primary immunodeficiency.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Small Cell / complications*
  • Carcinoma, Small Cell / pathology
  • Cecal Neoplasms / complications*
  • Cell Differentiation / physiology
  • Common Variable Immunodeficiency / complications*
  • Common Variable Immunodeficiency / pathology
  • Humans
  • Infant
  • Male