(6R)-6-(substituted methyl)penicillanic acid sulfones: new potent beta-lactamase inhibitors

S Adam; R Then; P Angehrn

doi:10.7164/antibiotics.46.641

(6R)-6-(substituted methyl)penicillanic acid sulfones: new potent beta-lactamase inhibitors

J Antibiot (Tokyo). 1993 Apr;46(4):641-6. doi: 10.7164/antibiotics.46.641.

Authors

S Adam¹, R Then, P Angehrn

Affiliation

¹ F. Hoffmann-La Roche AG, Basel, Switzerland.

PMID: 8388871
DOI: 10.7164/antibiotics.46.641

Abstract

A series of (6R)-6-(substituted methyl)penicillanic acid sulfones has been prepared starting from the corresponding 6-(substituted methylene)penicillanates. The new sulfones 9a, 9b, 9c and 9d have been shown to be potent beta-lactamase inhibitors.

MeSH terms

Animals
Mice
Microbial Sensitivity Tests
Penicillanic Acid / chemical synthesis
Penicillanic Acid / pharmacology*
Sepsis / drug therapy
Structure-Activity Relationship
Sulfones / chemical synthesis
Sulfones / pharmacology*
beta-Lactamase Inhibitors*

Substances

Sulfones
beta-Lactamase Inhibitors
Penicillanic Acid