Lagunamycin, a novel 5-lipoxygenase inhibitor. I. Taxonomy, fermentation, physico-chemical properties and biological characteristics

Y Nihei; M Hasegawa; K Suzuki; S Yamamoto; M Hanada; T Furumai; Y Fukagawa; T Oki

doi:10.7164/antibiotics.46.900

Lagunamycin, a novel 5-lipoxygenase inhibitor. I. Taxonomy, fermentation, physico-chemical properties and biological characteristics

J Antibiot (Tokyo). 1993 Jun;46(6):900-7. doi: 10.7164/antibiotics.46.900.

Authors

Y Nihei¹, M Hasegawa, K Suzuki, S Yamamoto, M Hanada, T Furumai, Y Fukagawa, T Oki

Affiliation

¹ Bristol-Myers Squibb Research Institute, Tokyo, Japan.

PMID: 8393850
DOI: 10.7164/antibiotics.46.900

Abstract

Lagunamycin, a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08 microM) without lipid peroxidation.

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Cells, Cultured
Chromatography, High Pressure Liquid
Diazonium Compounds / chemistry
Diazonium Compounds / isolation & purification*
Diazonium Compounds / pharmacology*
Fermentation
Lipoxygenase Inhibitors*
Mice
Microbial Sensitivity Tests
Quinolones / chemistry
Quinolones / isolation & purification*
Quinolones / pharmacology*
Streptomyces / chemistry*

Substances

Anti-Bacterial Agents
Diazonium Compounds
Lipoxygenase Inhibitors
Quinolones
lagunamycin