Abstract
The effect of the 10-day dexamethasone administration on serotonin-2 (5-HT2) and beta-adrenergic receptor binding sites was evaluated in rat cerebral cortex and hippocampus. The dexamethasone treatment (1, 2 and 5 mg/kg) significantly increased the density of the 5-HT2 receptor binding sites in a dose-dependent manner, whereas a decreased density of beta-adrenergic receptor binding sites was observed in rat cortex. In contrast, there were no significant differences in the densities of the 5-HT2 or beta-adrenergic receptor binding sites in rat hippocampus using dexamethasone. The results suggest that dexamethasone differentially modulates the 5-HT2 and beta-adrenergic receptor binding sites in rat brain.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Chemistry / drug effects*
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Cerebral Cortex / drug effects*
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Cerebral Cortex / metabolism
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Dexamethasone / administration & dosage
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Dexamethasone / pharmacology*
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Down-Regulation / drug effects
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Hippocampus / drug effects*
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Hippocampus / metabolism
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Ketanserin / metabolism
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Kinetics
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Male
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Organ Specificity
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Propanolamines / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Adrenergic, beta / drug effects*
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Receptors, Glucocorticoid / classification
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Receptors, Glucocorticoid / drug effects
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Receptors, Glucocorticoid / physiology*
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Receptors, Serotonin / drug effects*
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Up-Regulation / drug effects
Substances
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Propanolamines
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Receptors, Adrenergic, beta
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Receptors, Glucocorticoid
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Receptors, Serotonin
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dexamethasone receptor
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Dexamethasone
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Ketanserin
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CGP 12177