Abstract
Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.
MeSH terms
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Adenine Nucleotides / metabolism
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Animals
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Cell Line
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DNA / biosynthesis
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DNA / isolation & purification
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DNA / metabolism*
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DNA Damage*
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Electrophoresis, Agar Gel
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Humans
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Kinetics
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Lipoproteins, LDL / blood
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Lipoproteins, LDL / isolation & purification
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Lipoproteins, LDL / toxicity*
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Macrophages / drug effects
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Macrophages / metabolism*
Substances
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Adenine Nucleotides
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Lipoproteins, LDL
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DNA