(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist

J Med Chem. 1993 Sep 3;36(18):2703-5. doi: 10.1021/jm00070a015.
No abstract available

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Benzoates / chemical synthesis
  • Benzoates / pharmacology*
  • Benzoates / therapeutic use
  • Calcium / metabolism
  • Humans
  • Inflammation / drug therapy
  • Leukotriene B4 / pharmacology
  • Mice
  • Molecular Structure
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Pyridines / chemical synthesis
  • Pyridines / pharmacology*
  • Pyridines / therapeutic use
  • Receptors, Leukotriene B4 / antagonists & inhibitors*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzoates
  • Pyridines
  • Receptors, Leukotriene B4
  • (E)-3-((((6-(2-carboxyethenyl)-5-((8-(4-methoxyphenyl)octyl)oxy)-2-pyridinyl)methyl)thio)methyl)benzoic acid
  • Leukotriene B4
  • Calcium