Abstract
Recombinant vaccinia virus expressing the envelope proteins of type D retrovirus-Washington (SRV-2/W) was used to immunize macaques against SRV-2 infection. Four immunized macaques which had resisted a prior low-dose challenge were rechallenged with a high dose (10(6) infectious particles) of SRV-2 two years after being immunized. All four non-immunized control macaques became infected, but the four vaccinated animals resisted this intravenous challenge, as determined by the inability to detect SRV-2 in peripheral blood mononuclear cells and by the lack of seroconversion to new viral antigens.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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DNA, Viral / blood
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DNA, Viral / genetics
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Immunization
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Immunoblotting
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Macaca nemestrina
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Molecular Sequence Data
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Polymerase Chain Reaction
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Retroviruses, Simian / genetics
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Retroviruses, Simian / immunology*
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Retroviruses, Simian / isolation & purification
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / microbiology
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Simian Acquired Immunodeficiency Syndrome / prevention & control*
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Time Factors
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / pharmacology
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Vaccinia virus / immunology
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Viral Envelope Proteins / immunology
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Viral Vaccines / administration & dosage
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Viral Vaccines / pharmacology*
Substances
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DNA, Viral
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Vaccines, Synthetic
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Viral Envelope Proteins
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Viral Vaccines