Abstract
Two Macaca fascicularis with preexisting immunity to vaccinia virus were immunized twice with recombinant vaccinia virus expressing SIVmne gp160. Their SIV-specific antibody responses were lower than that of vaccinia-naive animals immunized similarly. Upon repeated boosting with gp160, the SIV-specific antibody titers in vaccinia-primed animals reached similar levels as vaccinia-naive animals and with comparable neutralizing titers. Both animals were protected against repeated intravenous challenge with low-dose SIVmne E11S. These results are significant because SIVmne E11S infection in M. fascicularis is pathogenic and leads to AIDS-like diseases.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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DNA, Viral / genetics
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Gene Products, env / genetics
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Gene Products, env / immunology*
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Immunization
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Immunization, Secondary
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Macaca fascicularis
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Molecular Sequence Data
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Simian Acquired Immunodeficiency Syndrome / etiology
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / prevention & control*
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology*
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Simian Immunodeficiency Virus / pathogenicity
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / pharmacology
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Vaccinia virus / immunology
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Viral Vaccines / administration & dosage
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Viral Vaccines / pharmacology*
Substances
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DNA, Viral
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Gene Products, env
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Vaccines, Synthetic
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Viral Vaccines