Abstract
Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Blood Proteins / metabolism
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Female
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Indoles / chemistry
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Indoles / metabolism*
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Indoles / therapeutic use*
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Isoindoles
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Leukemia L1210 / metabolism
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Mice
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Mice, Inbred C3H
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Neoplasms, Experimental / drug therapy*
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Photochemotherapy*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / metabolism*
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Photosensitizing Agents / therapeutic use*
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Pigments, Biological / chemistry
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Pigments, Biological / metabolism
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Pigments, Biological / therapeutic use
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Spectrometry, Fluorescence
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Blood Proteins
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Indoles
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Isoindoles
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Photosensitizing Agents
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Pigments, Biological
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phthalocyanine