Abstract
CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.
Publication types
-
Comparative Study
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adult
-
Diagnosis, Differential
-
Dopamine / physiology
-
Homovanillic Acid / cerebrospinal fluid*
-
Humans
-
Male
-
Personality Disorders / cerebrospinal fluid
-
Personality Disorders / diagnosis
-
Personality Disorders / physiopathology
-
Psychiatric Status Rating Scales
-
Schizotypal Personality Disorder / cerebrospinal fluid*
-
Schizotypal Personality Disorder / diagnosis
-
Schizotypal Personality Disorder / physiopathology
Substances
-
Dopamine
-
Homovanillic Acid