Abstract
Collagen induced arthritis (CIA) is an animal model of inflammatory polyarthritis. Immunotherapy with the monoclonal antibody F23.1, which deletes V beta 8 bearing T cells, significantly decreased the incidence of CIA in mice. Treatment with the monoclonal antibody 466B5, to delete V beta 6 bearing T cells in combination with F23.1 was no more effective than F23.1 alone and the CIA incidence in 466B5 treated animals was not significantly different from controls. Thus, the V beta 8 family of T cell receptor is expressed on self-reactive T cells in the CIA model of B10.RIII mice injected with porcine type II collagen.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology*
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Arthritis, Experimental / chemically induced
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Arthritis, Experimental / prevention & control*
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Arthritis, Experimental / therapy
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Cell Death / drug effects
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Collagen
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Disease Models, Animal
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Female
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Flow Cytometry
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Immunotherapy
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Male
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Mice
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Mice, Inbred Strains
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Receptors, Antigen, T-Cell, alpha-beta / analysis*
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T-Lymphocytes / drug effects
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T-Lymphocytes / pathology*
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T-Lymphocytes / ultrastructure
Substances
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Antibodies, Monoclonal
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Receptors, Antigen, T-Cell, alpha-beta
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Collagen