Abstract
Combination effect of UFT and CDDP against the rat prostatic carcinoma (R3327) was evaluated by the subrenal capsule assay in nude mice. The tumor growth of R3327 was inhibited in proportion to the UFT concentration. Anticancer effect of UFT was elevated by co-administration of CDDP. These data suggest a clinical usefulness of UFT administration with CDDP for hormonally refractory advanced prostatic carcinoma.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Combined Chemotherapy Protocols / pharmacology*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Body Weight / drug effects
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Cisplatin / administration & dosage
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Prostatic Neoplasms / drug therapy
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Prostatic Neoplasms / pathology*
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Rats
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Rats, Inbred F344
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Subrenal Capsule Assay*
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Tegafur / administration & dosage
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Tegafur / pharmacology
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Uracil / administration & dosage
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Uracil / pharmacology