Abstract
CD37, CD53, and R2 leukocyte surface antigens are members of a novel family of structurally related proteins. They all have four transmembrane-spanning domains with a single major extracellular loop. The CD37 is expressed on B cells and on a subpopulation of T cells. The CD53 is known as a panleukocyte marker. The R2 protein is an activation antigen of T cells. The CD37, CD53, and R2 genes were assigned with the help of human/rodent somatic cell hybrids and human-specific probes to human chromosomes 19, 1, and 11, respectively. For the regional assignment, various deletion hybrids were used to map CD37 to 19p13-q13.4, CD53 to 1p12-p31, and R2 to 11p12.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / genetics*
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Antigens, Differentiation / genetics*
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Antigens, Differentiation, T-Lymphocyte / genetics*
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Antigens, Neoplasm*
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Chromosome Mapping
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Chromosomes, Human, Pair 1
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 19
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Glycoproteins / genetics*
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Humans
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Kangai-1 Protein
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Membrane Glycoproteins / genetics*
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Multigene Family
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Proto-Oncogene Proteins*
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Tetraspanin 25
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Tetraspanins
Substances
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Antigens, CD
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Antigens, Differentiation
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Neoplasm
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CD37 protein, human
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CD53 protein, human
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CD82 protein, human
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Glycoproteins
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Kangai-1 Protein
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Membrane Glycoproteins
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Proto-Oncogene Proteins
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Tetraspanin 25
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Tetraspanins