Hydrometrocolpos following prenatal dexamethasone treatment for congenital adrenal hyperplasia (21-hydroxylase deficiency)

Eur J Pediatr. 1993 Jan;152(1):9-11. doi: 10.1007/BF02072507.

Abstract

A female with congenital adrenal hyperplasia (21-hydroxylase deficiency) received prenatal dexamethasone treatment. Suppression of the fetal adrenal was initially inadequate but adequate in later pregnancy. The baby showed masculinisation without clitoral enlargement and a narrow urogenital sinus with resulting hydrometrocolpos. It is possible that dexamethasone treatment which is initially inadequate increases the risk of this latter complication.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Hyperplasia, Congenital / complications
  • Adrenal Hyperplasia, Congenital / drug therapy*
  • Adult
  • Dexamethasone / administration & dosage*
  • Dexamethasone / adverse effects
  • Dexamethasone / therapeutic use
  • Female
  • Fetal Diseases / drug therapy*
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Prenatal Care
  • Urethral Diseases / etiology
  • Urethral Obstruction / etiology
  • Urinary Fistula / etiology
  • Uterine Diseases / etiology*
  • Vagina
  • Vaginal Diseases / etiology*
  • Vaginal Fistula / etiology

Substances

  • Dexamethasone