Abstract
A female with congenital adrenal hyperplasia (21-hydroxylase deficiency) received prenatal dexamethasone treatment. Suppression of the fetal adrenal was initially inadequate but adequate in later pregnancy. The baby showed masculinisation without clitoral enlargement and a narrow urogenital sinus with resulting hydrometrocolpos. It is possible that dexamethasone treatment which is initially inadequate increases the risk of this latter complication.
MeSH terms
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Adrenal Hyperplasia, Congenital / complications
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Adrenal Hyperplasia, Congenital / drug therapy*
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Adult
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Dexamethasone / administration & dosage*
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Dexamethasone / adverse effects
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Dexamethasone / therapeutic use
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Female
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Fetal Diseases / drug therapy*
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Humans
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Infant, Newborn
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Pregnancy
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Prenatal Care
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Urethral Diseases / etiology
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Urethral Obstruction / etiology
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Urinary Fistula / etiology
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Uterine Diseases / etiology*
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Vagina
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Vaginal Diseases / etiology*
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Vaginal Fistula / etiology