DXS539, a polymorphic DNA marker proximal of the fragile-X gene

J C Dreesen; J A van den Hurk; A P Smits; A M van den Ouweland; P W Markslag; B A van Oost

doi:10.1007/BF00230229

DXS539, a polymorphic DNA marker proximal of the fragile-X gene

Hum Genet. 1993 Mar;91(1):80-2. doi: 10.1007/BF00230229.

Authors

J C Dreesen¹, J A van den Hurk, A P Smits, A M van den Ouweland, P W Markslag, B A van Oost

Affiliation

¹ Department of Human Genetics, University Hospital Nijmegen, The Netherlands.

PMID: 8454292
DOI: 10.1007/BF00230229

Abstract

We report a new polymorphic DNA marker (pJH89, DXS539) proximal to the fragile-X site. The pJH89 probe identifies a TaqI and a NcoI restriction fragment length polymorphism (combined heterozygosity of 42%) and is linked to the fragile-X locus with a maximal LOD score of 12 at 4 cM. Multipoint linkage analysis and physical mapping studies indicate that the pJH89 probe is located within in the interval defined by the markers DXS369 and DXS548.

MeSH terms

Chromosome Fragility*
Female
Fragile X Syndrome / genetics*
Genetic Linkage / genetics*
Genetic Markers
Humans
Lod Score
Male
Polymorphism, Genetic / genetics*

Substances

Genetic Markers