Osteogenesis imperfecta and hyperplastic callus formation: light- and electron-microscopic findings

Am J Med Genet. 1993 Jan 15;45(2):260. doi: 10.1002/ajmg.1320450222.

Abstract

In rare cases of osteogenesis imperfecta, an "overshoot" growth of new bone may occur, which, clinically gives the impression of a tumour. This condition is known as hyperplastic callus formation. Morphology showed an excessive mixed desmal-chondral osteoneogenesis. Atypical collagen fibrils in non-callus tissue represent an indicator for this callus formation in individual patients.

MeSH terms

  • Bony Callus / pathology*
  • Humans
  • Hyperplasia
  • Microscopy, Electron
  • Osteogenesis Imperfecta / complications
  • Osteogenesis Imperfecta / pathology*