Abstract
Cisplatin exerts an additional influence on myocardial ischemia induced by the cardiovascular effects of etoposide. Two cases of myocardial ischemia related to combination chemotherapy with methotrexate, etoposide and cisplatin are reported. While the major toxicity associated with systemic chemotherapy is hematologic, it is suggested that, in elderly patients with increased incidence of atherosclerotic disease, special attention be given to vascular complications of antineoplastic agents.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cisplatin / administration & dosage
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Cisplatin / adverse effects
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Etoposide / administration & dosage
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Etoposide / adverse effects
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Humans
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Male
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Methotrexate / administration & dosage
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Methotrexate / adverse effects
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Middle Aged
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Myocardial Ischemia / chemically induced*
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Myocardial Ischemia / diagnosis
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Urinary Bladder Neoplasms / drug therapy
Substances
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Etoposide
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Cisplatin
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Methotrexate