Abstract
The effects of high-dose ketamine on the c-fos protein (c-Fos) expression were investigated in rat by an immunohistochemical technique. The administration of 100 mg/kg ketamine i.p. induced seizure-like activity (limbic seizure). No c-Fos immunoreactivity was observed in hippocampus, piriform cortex and amygdala, while it was observed in neocortex and thalamus. These findings disagree with the reports that ketamine depresses the neuronal function of the neocortex and thalamus, while it stimulates the limbic system.
MeSH terms
-
Amygdala / drug effects
-
Amygdala / metabolism
-
Animals
-
Behavior, Animal / drug effects
-
Cerebral Cortex / drug effects
-
Cerebral Cortex / metabolism
-
Hippocampus / drug effects
-
Hippocampus / metabolism*
-
Immunohistochemistry
-
In Vitro Techniques
-
Kainic Acid / pharmacology
-
Ketamine / pharmacology*
-
Male
-
N-Methylaspartate / antagonists & inhibitors
-
Proto-Oncogene Proteins c-fos / biosynthesis*
-
Proto-Oncogene Proteins c-fos / immunology
-
Rats
-
Rats, Wistar
-
Seizures / chemically induced
-
Seizures / metabolism
-
Thalamus / drug effects
-
Thalamus / metabolism
Substances
-
Proto-Oncogene Proteins c-fos
-
N-Methylaspartate
-
Ketamine
-
Kainic Acid