Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder

Am J Psychiatry. 1993 May;150(5):819-21. doi: 10.1176/ajp.150.5.819.

Abstract

In a double-blind, crossover study, 13 fluoxetine-treated patients with obsessive-compulsive disorder were given adjuvant buspirone and placebo for 4 weeks each. There were no significant differences between buspirone and placebo in obsessive-compulsive, depressive, or anxiety symptoms.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy
  • Anxiety Disorders / psychology
  • Buspirone / therapeutic use*
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Fluoxetine / therapeutic use*
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / drug therapy*
  • Obsessive-Compulsive Disorder / psychology
  • Placebos

Substances

  • Placebos
  • Fluoxetine
  • Buspirone