Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control

S Kawamoto; Y Amaya; S Hattori; Y Miyagi; H Onishi; K Okuda

doi:10.1016/0167-4781(93)90255-c

Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control

Biochim Biophys Acta. 1993 Apr 29;1173(1):111-4. doi: 10.1016/0167-4781(93)90255-c.

Authors

S Kawamoto¹, Y Amaya, S Hattori, Y Miyagi, H Onishi, K Okuda

Affiliation

¹ Department of Bacteriology, Yokohama City University School of Medicine, Japan.

PMID: 8485149
DOI: 10.1016/0167-4781(93)90255-c

Abstract

The present detailed analysis of the sequence of the extremely long (967 bp) 5'-noncoding region of a rat brain argininosuccinate lyase cDNA clone, reveals several features of interest. Multiple copies of partial and inverted (antisense) B1 repeats and multiple upstream ATG codons are present in the region, which suggests a possibility of translational control of the argininosuccinate lyase gene expression in rat brain.

MeSH terms

Amino Acid Sequence
Animals
Argininosuccinate Lyase / genetics*
Base Sequence
Brain / enzymology*
Codon
Molecular Sequence Data
Multigene Family
Protein Biosynthesis
RNA, Messenger / analysis*
Rats

Substances

Codon
RNA, Messenger
Argininosuccinate Lyase

Associated data

GENBANK/D13124
GENBANK/D13127
GENBANK/D13132
GENBANK/D13133
GENBANK/D13134
GENBANK/D13135
GENBANK/D13136
GENBANK/D13137
GENBANK/D13978
GENBANK/L08068