Change of paraprotein from IgG lambda to lambda chain in myeloma

M Sawamura; K Murayama; S Tokizawa; T Matsushima; J Tamura; H Murakami; T Naruse; J Tsuchiya

doi:10.1007/BF01703239

Change of paraprotein from IgG lambda to lambda chain in myeloma

Ann Hematol. 1993 Apr;66(4):215-6. doi: 10.1007/BF01703239.

Authors

M Sawamura¹, K Murayama, S Tokizawa, T Matsushima, J Tamura, H Murakami, T Naruse, J Tsuchiya

Affiliation

¹ Third Department of Internal Medicine, Gunma University School of Medicine, Japan.

PMID: 8485210
DOI: 10.1007/BF01703239

Abstract

We describe a unique case of IgG lambda myeloma in which a plasma cell leukemia developed and the paraprotein changed from IgG lambda to lambda chain, the latter inducing fatal renal failure. In addition, J-chain was detected in the cytoplasm of the plasma cell leukemia cells.

Publication types

Case Reports

MeSH terms

Female
Humans
Immunoglobulin G / blood
Immunoglobulin G / metabolism*
Immunoglobulin J-Chains / metabolism*
Immunoglobulin lambda-Chains / blood
Immunoglobulin lambda-Chains / metabolism*
Leukemia, Plasma Cell / blood
Leukemia, Plasma Cell / metabolism*
Middle Aged
Multiple Myeloma / blood
Multiple Myeloma / metabolism*

Substances

Immunoglobulin G
Immunoglobulin J-Chains
Immunoglobulin lambda-Chains