Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23

Genomics. 1993 Apr;16(1):266-8. doi: 10.1006/geno.1993.1174.

Abstract

The upstream stimulatory factor, USF, is a ubiquitously expressed cellular transcription factor that binds to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters. A full-length cDNA encoding the 43-kDa USF protein has previously been isolated. USF contains both helix-loop-helix and leucine repeats, which are involved in regulating its DNA binding and dimerization properties. We report the use of mouse-human somatic cell hybrids and in situ hybridization in localizing the gene-encoding USF to human chromosome 1q22-q23.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • DNA / genetics
  • DNA Probes
  • DNA-Binding Proteins / genetics*
  • Humans
  • Hybrid Cells
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Transcription Factors / genetics*
  • Upstream Stimulatory Factors

Substances

  • DNA Probes
  • DNA-Binding Proteins
  • Transcription Factors
  • USF1 protein, human
  • Upstream Stimulatory Factors
  • Usf1 protein, mouse
  • DNA