Abstract
The last few years have seen an enormous jump in our knowledge and understanding of T-cell activation by superantigens. Clearly, a great number of infectious and parasitic organisms utilize superantigens as part of a strategy to evade the immune response of their host. The ability to modulate superantigen effects will give us new means to fight infections, and the knowledge of T-cell activation that we have gained from study of superantigens will, in turn, allow us to modulate the immune system in new ways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Bacterial / genetics
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Antigens, Bacterial / metabolism
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Binding Sites
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Enterotoxins / genetics
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Enterotoxins / immunology
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Enterotoxins / metabolism*
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HLA-DR Antigens / metabolism
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Histocompatibility Antigens Class II / metabolism
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Humans
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Mutation
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Receptors, Antigen, T-Cell, alpha-beta / metabolism*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / immunology
Substances
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Antigens, Bacterial
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Enterotoxins
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HLA-DR Antigens
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Histocompatibility Antigens Class II
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Receptors, Antigen, T-Cell, alpha-beta