Abstract
The growth hormone response to the acetylcholinesterase inhibitor pyridostigmine was measured in nine normothymic outpatients who met DSM-III-R criteria for obsessive-compulsive disorder. The responses were significantly elevated when compared to those found in a healthy comparison group (N = 9). The data suggest that cholinergic supersensitivity is present in obsessive-compulsive disorder.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Ambulatory Care
-
Female
-
Growth Hormone / blood*
-
Humans
-
Male
-
Middle Aged
-
Obsessive-Compulsive Disorder / blood
-
Obsessive-Compulsive Disorder / diagnosis*
-
Obsessive-Compulsive Disorder / physiopathology
-
Parasympathetic Nervous System / drug effects
-
Parasympathetic Nervous System / physiopathology
-
Pyridostigmine Bromide* / pharmacology
-
Receptors, Cholinergic / drug effects
-
Receptors, Cholinergic / physiology
Substances
-
Receptors, Cholinergic
-
Growth Hormone
-
Pyridostigmine Bromide