Abstract
Although myelofibrosis has been described in systemic lupus erythematosus (SLE), this coexistence must be rare since there are few reports showing this combination. The possible relationship between hematologic abnormalities and SLE remains unresolved. The authors describe a 39-year-old woman with persistent neutropenia and SLE in whom myelofibrosis was found. Unlike previously reported cases, myelofibrosis did not resolve with steroid therapy. In this report, the clinical course of the patient is compared with others described in the literature.
MeSH terms
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Adult
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Biopsy
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Bone Marrow / pathology
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Drug Therapy, Combination
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Female
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Humans
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Leukocyte Count / drug effects
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Lupus Erythematosus, Systemic / blood
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Lupus Erythematosus, Systemic / complications*
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Lupus Erythematosus, Systemic / drug therapy
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Lupus Erythematosus, Systemic / pathology
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Methylprednisolone / administration & dosage
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Neutropenia / blood
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Neutropenia / drug therapy
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Neutropenia / etiology*
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Neutropenia / pathology
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Neutrophils / drug effects
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Prednisone / administration & dosage
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Primary Myelofibrosis / blood
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Primary Myelofibrosis / drug therapy
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Primary Myelofibrosis / etiology*
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Primary Myelofibrosis / pathology
Substances
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Prednisone
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Methylprednisolone