Abstract
The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.
MeSH terms
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Animals
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Combined Modality Therapy
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Femoral Artery / surgery
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Hindlimb / blood supply
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Ischemia / drug therapy*
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Ischemia / surgery
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Male
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Microscopy, Electron
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Microsurgery
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Polyethylene Glycols / administration & dosage
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Rats
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Rats, Wistar
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Reactive Oxygen Species / metabolism
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Reperfusion Injury / prevention & control*
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Superoxide Dismutase / administration & dosage
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Superoxide Dismutase / pharmacokinetics
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Superoxide Dismutase / therapeutic use*
Substances
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Reactive Oxygen Species
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Polyethylene Glycols
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monomethoxypolyethylene glycol
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Superoxide Dismutase