Localization of the CDKN4/p27Kip1 gene to human chromosome 12p12.3

Hum Genet. 1995 Dec;96(6):668-70. doi: 10.1007/BF00210296.

Abstract

CDKN4/p27Kip1 is a cyclin-dependent kinase (Cdk) inhibitor implicated in G1 phase arrest, which negatively regulates G1 phase progression in response to TGF beta, and might represent a tumor suppressor gene. We report here the chromosomal assignment of the human CDKN4 gene to chromosome 12p12.3 in close proximity to highly polymorphic microsatellite markers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cell Cycle Proteins*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases / antagonists & inhibitors*
  • DNA Primers
  • Enzyme Inhibitors
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lymphocytes / metabolism
  • Microtubule-Associated Proteins / genetics*
  • Molecular Sequence Data
  • Polymerase Chain Reaction / methods
  • Tumor Suppressor Proteins*

Substances

  • Cell Cycle Proteins
  • DNA Primers
  • Enzyme Inhibitors
  • Microtubule-Associated Proteins
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases