Abstract
CDKN4/p27Kip1 is a cyclin-dependent kinase (Cdk) inhibitor implicated in G1 phase arrest, which negatively regulates G1 phase progression in response to TGF beta, and might represent a tumor suppressor gene. We report here the chromosomal assignment of the human CDKN4 gene to chromosome 12p12.3 in close proximity to highly polymorphic microsatellite markers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Cell Cycle Proteins*
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Chromosome Mapping
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Chromosomes, Human, Pair 12*
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Cyclin-Dependent Kinase Inhibitor p27
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Cyclin-Dependent Kinases / antagonists & inhibitors*
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DNA Primers
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Enzyme Inhibitors
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Humans
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In Situ Hybridization, Fluorescence
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Lymphocytes / metabolism
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Microtubule-Associated Proteins / genetics*
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Tumor Suppressor Proteins*
Substances
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Cell Cycle Proteins
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DNA Primers
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Enzyme Inhibitors
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Microtubule-Associated Proteins
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Tumor Suppressor Proteins
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Cyclin-Dependent Kinase Inhibitor p27
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Cyclin-Dependent Kinases