Abstract
Cyclic ADP-ribose is a recently discovered metabolite of NAD that functions in cellular calcium signalling. The discovery that NAD glycohydrolases can catalyze the synthesis and hydrolysis of cyclic ADP-ribose has renewed interest in this class of ADP-ribose transferring enzymes that were discovered over 50 years ago.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenosine Diphosphate Ribose / analogs & derivatives*
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Adenosine Diphosphate Ribose / chemistry
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Adenosine Diphosphate Ribose / metabolism
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Animals
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Calcium / metabolism
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Cyclic ADP-Ribose
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Humans
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NAD / metabolism*
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NAD+ Nucleosidase / metabolism*
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Signal Transduction
Substances
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NAD
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Cyclic ADP-Ribose
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Adenosine Diphosphate Ribose
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NAD+ Nucleosidase
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Calcium