DNA separation with field inversion capillary electrophoresis

Electrophoresis. 1995 Aug;16(8):1423-8. doi: 10.1002/elps.11501601235.

Abstract

We have built an automated pulsed field capillary electrophoresis system on the basis of a commercially available device. Using entangled polymer solutions as separating matrix, we demonstrate a considerable improvement of separation of double-stranded DNA in the range of 1-50 kbp under pulsed field conditions. The influence of the main parameters, i.e. pulse frequency and electric field, is studied and the results are compared to existing electrophoresis theories.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoanalysis
  • Bacteriophage T4 / genetics
  • Bacteriophage lambda / genetics
  • Bacteriophage phi X 174 / genetics
  • DNA, Viral / isolation & purification*
  • Electricity
  • Electrophoresis
  • Electrophoresis, Capillary / methods*
  • Electrophoresis, Capillary / statistics & numerical data
  • Models, Chemical
  • Polymers
  • Solutions
  • Time Factors

Substances

  • DNA, Viral
  • Polymers
  • Solutions