Comparison among different ovarian stimulation regimens for assisted procreation procedures in patients with endometriosis

Hum Reprod. 1995 Sep;10(9):2406-11. doi: 10.1093/oxfordjournals.humrep.a136308.

Abstract

The objective of our study was to establish the most adequate ovarian stimulation regimen for assisted procreation in endometriotic patients. It consisted of a retrospective analysis comparing the use of the gonadotrophin-releasing hormone analogue (GnRHa) buserelin either for 3 months or for 3 weeks and continued with ovarian stimulation with human menopausal gonadotrophin (HMG), and the use of clomiphene citrate in association with HMG for in-vitro fertilization (IVF) and embryo transfer, gamete intra-Fallopian transfer (GIFT) and zygote intra-Fallopian transfer (ZIFT). A total of 145 patients with endometriosis in 174 cycles were divided into two groups according to the revised American Fertility Society staging of the disease (group A, stages 1 and 2; group B, stages 3 and 4). The use of GnRHa significantly increased the number of oocytes retrieved. GnRH analogues for 3 months gave the highest fertilization rate for groups A and B. The cleavage, pregnancy and delivery rates, although higher in the groups treated with analogues, did not reach statistical significance. A higher number of patients had an embryo transfer in the groups treated with GnRHa (P < 0.05). Treatment with GnRHa for either 3 months or for 3 weeks proved to be more efficient than clomiphene citrate-HMG for assisted procreation procedures in patients with endometriosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Buserelin / therapeutic use
  • Cleavage Stage, Ovum
  • Clomiphene / therapeutic use
  • Cryopreservation
  • Embryo Implantation
  • Endometriosis / complications*
  • Female
  • Fertilization in Vitro*
  • Gamete Intrafallopian Transfer*
  • Humans
  • Infertility, Female / etiology
  • Infertility, Female / therapy*
  • Menotropins / therapeutic use
  • Ovulation Induction / methods*
  • Pregnancy
  • Pregnancy, Ectopic
  • Pregnancy, Multiple
  • Retrospective Studies
  • Zygote Intrafallopian Transfer*

Substances

  • Clomiphene
  • Menotropins
  • Buserelin