Abstract
The neurotoxic actions of MPTP and its 4-(O-tolyl) analog (2'-Me-MPTP) on two breeds of rabbits were investigated. MPTP, but not 2'-Me-MPTP, causes a reduction (about 40%) in striatal dopamine content in rabbits of the "little silver-black" breed. The dopamine content of striata of "chinchilla" rabbits was not affected by either agent.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / analogs & derivatives
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Animals
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Behavior, Animal / drug effects
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Corpus Striatum / metabolism
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Dopamine / metabolism
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Dopamine Agents / toxicity*
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Dopamine Antagonists / toxicity
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MPTP Poisoning*
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Nervous System Diseases / chemically induced*
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Nervous System Diseases / physiopathology
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Nervous System Diseases / psychology
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Rabbits
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Species Specificity
Substances
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Dopamine Agents
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Dopamine Antagonists
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1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Dopamine