Acid-base changes after severe birth acidaemia

J Perinat Med. 1995;23(4):249-55. doi: 10.1515/jpme.1995.23.4.249.

Abstract

The aim of this study was to assess prospectively acid-base changes after severe birth acidaemia. Fourty-five term babies with severe acidaemia (median umbilical artery pH 6.99 [Range 6.74-7.05], mean base deficit 16.3 [SD 3.7] mmol/l) were prospectively identified. Pathological cardiotocographs were present in 32 (71%) prior to delivery and 39 (87%) were delivered operatively; 27 for fetal distress. Sixteen required intubation. At one hour of age, median pH was 7.29 [Range 7.04-7.45] and the change in pH correlated with one hour pCO2 (r = 0.62 p < 0.001). pH measurements were obtained in 11 of the 16 babies with a 1 hour pH < or = 7.25 and all values had recovered by this time. Five of this group were receiving oxygen. Of the 11 babies admitted to NICU, 1 died and 3 had evidence of encephalopathy, all of which were normal at follow-up [2-12 months]. Recovery of pH after severe birth acidaemia was evident at 1 hour of age and would appear to be complete by 4 hours.

MeSH terms

  • Acid-Base Imbalance / physiopathology*
  • Acidosis / blood*
  • Acidosis / congenital
  • Adaptation, Physiological
  • Adult
  • Female
  • Follow-Up Studies
  • Humans
  • Hydrogen-Ion Concentration
  • Infant, Newborn
  • Linear Models
  • Pregnancy
  • Prospective Studies
  • Umbilical Arteries