Abstract
In this study the expression of 'classically' considered lymphoid-associated antigens (CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD19, CD20, and CD22) was explored both in peripheral blood (PB) and bone marrow (BM) mast cells (MC) in a case of systemic mast cell disease (SMCD) by means of using multiple stainings and a direct immunofluorescence technique. CD2 and CD22 were expressed in both PB and BM MC, all the remaining lymphoid-associated markers were negative. Our results suggest that the reactivity for both CD2 and CD22 in PB and BM MC would be aberrant.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antigens, CD / analysis*
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Antigens, Differentiation, B-Lymphocyte / analysis
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Biomarkers / analysis
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Bone Marrow / immunology*
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CD2 Antigens / analysis
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Cell Adhesion Molecules / analysis
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Flow Cytometry
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Fluorescent Antibody Technique, Direct
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Humans
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Immunophenotyping
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Lectins*
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Leukemia, Mast-Cell / immunology*
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Male
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Mast Cells / immunology*
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Sialic Acid Binding Ig-like Lectin 2
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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Biomarkers
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CD2 Antigens
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CD22 protein, human
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Cell Adhesion Molecules
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Lectins
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Sialic Acid Binding Ig-like Lectin 2