Abstract
A new TaqI/DQA restriction fragment length polymorphism (RFLP) has been found in two Spanish Caucasoid individuals. The novel polymorphic fragment has a relative mobility of 4.2 kb and is associated with an HLA-A2,Cw*1401,B51,DR9,DR53,DQ9 haplotype. Nucleotide sequence analysis indicates that individuals showing this RFLP pattern do not carry a new DQA1 allele, but that (DQA1*0302) commonly observed in DR9,DQ9 haplotypes. The new RFLP seems to be a locally restricted marker of uncertain origin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Base Sequence
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Deoxyribonucleases, Type II Site-Specific*
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Female
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HLA-DQ Antigens / genetics*
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HLA-DQ alpha-Chains
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HLA-DR Antigens / genetics*
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HLA-DR Serological Subtypes
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Haplotypes / genetics
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Humans
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Male
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Molecular Sequence Data
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Pedigree
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Polymorphism, Restriction Fragment Length*
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Spain
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White People / genetics
Substances
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HLA-DQ Antigens
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HLA-DQ alpha-Chains
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HLA-DQA1 antigen
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HLA-DR Antigens
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HLA-DR Serological Subtypes
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HLA-DR9 antigen
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Deoxyribonucleases, Type II Site-Specific
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TCGA-specific type II deoxyribonucleases