Abstract
Homologs of the dimeric HU protein of Escherichia coli can be found in every prokaryotic organism that has been analyzed. In this work, we demonstrate that Serratia marcescens synthesizes two distinct HU subunits, like E. coli and Salmonella typhimurium, suggesting that the heterodimeric HU protein could be a common feature of enteric bacteria. A phylogenetic analysis of the HU-type proteins (HU and IHF) is presented, and a scheme for the origin of the hup genes and the onset of HU heterodimericity is suggested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / biosynthesis
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics*
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Base Sequence
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Cloning, Molecular
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DNA-Binding Proteins / biosynthesis
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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Escherichia coli / genetics*
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Genes, Bacterial / genetics
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Integration Host Factors
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Molecular Sequence Data
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Phylogeny
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Salmonella typhimurium / genetics*
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
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Serratia marcescens / genetics*
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Integration Host Factors
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histone-like protein HU, bacteria
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integration host factor, Salmonella
Associated data
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GENBANK/L25627
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GENBANK/L35044
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GENBANK/L35257
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GENBANK/L35258
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GENBANK/U25149
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GENBANK/U25150
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GENBANK/U32727
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GENBANK/U32802
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GENBANK/U32810
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GENBANK/Z33259
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PIR/S00053
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SWISSPROT/P02341
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SWISSPROT/P02342
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SWISSPROT/P02345
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SWISSPROT/P02346
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SWISSPROT/P05385
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SWISSPROT/P05514
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SWISSPROT/P05515
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SWISSPROT/P06984
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SWISSPROT/P08756
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SWISSPROT/P08821
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SWISSPROT/P15148
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SWISSPROT/P15430
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SWISSPROT/P19436
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SWISSPROT/P23302
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SWISSPROT/P23303
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SWISSPROT/P28080
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SWISSPROT/P29214
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SWISSPROT/P30787
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SWISSPROT/Q06607