Abstract
We report a 18 years old female with Lennox-Gastaut syndrome under treatment with sodium valproate, carbamazepine and clonazepam. When seizures increased we stopped carbamazepine and introduced lamotrigine slowly. One month later the girl developed haemorrhagic erosions in mucoses and limbs with deterioration of her general state. Skin biopsy confirmed the diagnosis of erythema multiforme, the Stevens-Johnson's form. The immediate withdrawal of lamotrigine and treatment with antihystaminics and steroids was followed of a slowly favourable course with disappearance of symptomatology one month later. It's another case of Stevens-Johnson syndrome related to the introduction of lamotrigine in polytherapy.
MeSH terms
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Adolescent
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Anticonvulsants / administration & dosage
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Anticonvulsants / adverse effects*
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Anticonvulsants / therapeutic use
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Carbamazepine / administration & dosage
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Carbamazepine / therapeutic use
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Clonazepam / administration & dosage
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Clonazepam / therapeutic use
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Dose-Response Relationship, Drug
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Drug Therapy, Combination
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Epidermis / pathology
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Epidermis / ultrastructure
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Epilepsy / drug therapy
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Female
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Humans
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Lamotrigine
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Necrosis / pathology
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Stevens-Johnson Syndrome / etiology*
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Stevens-Johnson Syndrome / pathology
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Triazines / administration & dosage
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Triazines / adverse effects*
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Triazines / therapeutic use
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Valproic Acid / administration & dosage
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Valproic Acid / therapeutic use
Substances
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Anticonvulsants
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Triazines
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Carbamazepine
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Clonazepam
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Valproic Acid
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Lamotrigine