Abstract
Twenty ASA I-II patients received either 2 or 3 x ED95 doses of rocuronium bromide during nitrous oxide, oxygen, propofol, fentanyl-based anaesthesia. The mean times to maximum block were 98 s and 74 s and the mean duration of clinical relaxation (recovery to 25% T1) was 35 min and 46 min following 620 micrograms kg-1 and 930 micrograms kg-1, respectively. Neuromuscular blockade was antagonized with either neostigmine or edrophonium from a twitch height of 25%. Although there was no significant difference between the recovery times neostigmine appeared to give more consistent antagonism of rocuronium-induced blockade.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adolescent
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Adult
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Androstanols / administration & dosage
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Androstanols / antagonists & inhibitors
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Androstanols / pharmacology*
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Anesthesia
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Cholinesterase Inhibitors / pharmacology
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Double-Blind Method
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Edrophonium / pharmacology
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Humans
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Middle Aged
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Muscle Relaxation / drug effects
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Neostigmine / pharmacology
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Neuromuscular Nondepolarizing Agents / administration & dosage
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Neuromuscular Nondepolarizing Agents / antagonists & inhibitors
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Neuromuscular Nondepolarizing Agents / pharmacology*
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Rocuronium
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Time Factors
Substances
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Androstanols
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Cholinesterase Inhibitors
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Neuromuscular Nondepolarizing Agents
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Neostigmine
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Edrophonium
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Rocuronium