Hemodialysis is an efficient therapy for endstage renal failure. This treatment, however, must be used in an optimal fashion, i.e., with the best technology and the most adequate schedules. Unfortunately and especially for economic reasons, these basic therapeutic principles are often not respected. As a consequence, morbidity and mortality in maintenance hemodialysis patients have increased. This article underlines four points that could influence mortality in maintenance hemodialysis patients: nutrition, adequacy of hemodialysis, blood pressure control and treatment time.