Abstract
Indwelling device infections are associated with considerable morbidity and extremely high cost. Pseudomonas aeruginosa is the most frequent gram-negative etiologic agent associated with infections of indwelling catheters and foreign body implants. It is generally agreed that eradication of infection in the presence of a foreign body requires removal of the foreign body. Using a combination of ceftazidime and ciprofloxacin, we cured nine of nine patients with P. aeruginosa-infected osteosynthetic material and four of five patients with hip and knee prostheses without removing the foreign material. Follow-up was for a mean of 21 months (range, 6 to 60 months). Some patients experienced minor side effects (arthralgia in one patient and rash in another patient). We conclude that this combination is effective and safe and should be useful in the treatment of P. aeruginosa-infected orthopedic implants.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / adverse effects
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Anti-Infective Agents / therapeutic use
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Ceftazidime / administration & dosage
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Ceftazidime / adverse effects
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Ceftazidime / therapeutic use
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Cephalosporins / administration & dosage
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Cephalosporins / adverse effects
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Cephalosporins / therapeutic use
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Ciprofloxacin / administration & dosage
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Ciprofloxacin / adverse effects
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Ciprofloxacin / therapeutic use
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Drug Therapy, Combination / administration & dosage
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Drug Therapy, Combination / adverse effects
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Drug Therapy, Combination / therapeutic use*
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Prospective Studies
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Prosthesis-Related Infections / blood
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Pseudomonas Infections / drug therapy*
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Pseudomonas Infections / microbiology
Substances
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Anti-Infective Agents
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Cephalosporins
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Ciprofloxacin
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Ceftazidime