Novel prostanoid thromboxane A2 agonists

K D Joachim; U Klar; A Pletsch; H Rehwinkel; W Skuballa

doi:10.1016/0090-6980(95)00048-8

Novel prostanoid thromboxane A2 agonists

Prostaglandins. 1995 Aug;50(2):57-63. doi: 10.1016/0090-6980(95)00048-8.

Authors

K D Joachim¹, U Klar, A Pletsch, H Rehwinkel, W Skuballa

Affiliation

¹ Research Laboratories of Schering AG, Berlin, Germany.

PMID: 8588073
DOI: 10.1016/0090-6980(95)00048-8

Abstract

The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 10 times more potent than the standard TP-receptor against U 46619.

MeSH terms

Blood Platelets / metabolism
Cell Membrane / metabolism
Humans
Platelet Aggregation / drug effects
Prostaglandins D / chemical synthesis
Prostaglandins D / pharmacology*
Receptors, Thromboxane / metabolism
Thromboxane A2 / agonists*

Substances

9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor-5,13-prostadienoic acid
Prostaglandins D
Receptors, Thromboxane
Thromboxane A2