Abstract
The effect of a novel thromboxane A2 receptor antagonist, BAY-u-3405, on experimental allergic airway and skin reactions was studied in vivo. At doses of 3-30 mg/kg BAY-u-3405 clearly inhibited the U-46619-induced increase in respiratory resistance (Rrs) in guinea pigs. BAY-u-3405 at doses of 3 and 30 mg/kg inhibited the aerosolized antigen-induced biphasic increase in respiratory resistance in guinea pigs. Moreover, BAY-u-3405 inhibited repeated aeroantigen-induced airway hyperactivity and airway inflammation in mice. In IgE antibody-mediated biphasic skin reactions in mice, both immediate and late-phase reactions were inhibited by 10 mg/kg of BAY-u-3405. These results demonstrate the efficacy of BAY-u-3405 on the antigen-induced late-phase reactions in the airway and skin in guinea pigs and mice, and antigen-induced airway hyperactivity in mice.
MeSH terms
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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Animals
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Bronchial Hyperreactivity / drug therapy*
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Bronchial Hyperreactivity / immunology
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Carbazoles / pharmacology*
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Dermatitis / drug therapy*
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Dermatitis / immunology
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Guinea Pigs
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Hypersensitivity / drug therapy*
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Hypersensitivity / immunology
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Immunoglobulin E / adverse effects
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Male
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Mice
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Mice, Inbred BALB C
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Platelet Aggregation Inhibitors / pharmacology*
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Prostaglandin Endoperoxides, Synthetic / pharmacology
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Receptors, Thromboxane / antagonists & inhibitors*
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Sulfonamides / pharmacology*
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Thromboxane A2 / analogs & derivatives
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Thromboxane A2 / pharmacology
Substances
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Carbazoles
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Platelet Aggregation Inhibitors
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Prostaglandin Endoperoxides, Synthetic
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Receptors, Thromboxane
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Sulfonamides
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Immunoglobulin E
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Thromboxane A2
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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ramatroban