Abstract
We studied 18 patients with acute promyelocytic leukaemia and 13 with relapsed APL. We found a significantly elevated EGF in acute leukaemia, especially in APL, being 418.59 +/- 19.2 micrograms in the 24-h urine that was much higher than that of the normal controls. When eight APL patients achieved complete remission by RA treatment, the EGF value decreased to 149.9 +/- 27.3 micrograms in the 24-h urine near to normal. In 13 patients with relapsed APL, EGF rose to 446.9 +/- 82.6 micrograms in the 24-h urine. Most interestingly, this elevated EGF could be detected before the relapse by 5 +/- 0.84 months in seven out of eight APL with relapse. We suggest that the unaccountably elevated EGF during remission period may be an indicator of the occurrence of relapse.
MeSH terms
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Acute Disease
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Adult
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Aged
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Base Sequence
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Biomarkers, Tumor / urine*
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Cell Differentiation / drug effects
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Epidermal Growth Factor / urine*
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Female
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Humans
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Immunologic Factors / therapeutic use*
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Leukemia, Myeloid / urine
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Leukemia, Promyelocytic, Acute / drug therapy
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Leukemia, Promyelocytic, Acute / therapy*
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Leukemia, Promyelocytic, Acute / urine
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Male
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Middle Aged
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Molecular Sequence Data
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Neoplasm Proteins / analysis
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Neoplasm Proteins / urine*
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Neoplasm Recurrence, Local / urine
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Neoplasm, Residual
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Oncogene Proteins, Fusion / analysis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / urine
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Remission Induction
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Tretinoin / therapeutic use*
Substances
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Biomarkers, Tumor
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Immunologic Factors
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Neoplasm Proteins
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Oncogene Proteins, Fusion
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promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
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Tretinoin
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Epidermal Growth Factor