Occurrence of a T cell lymphoma in a patient with chronic myeloid leukemia treated with alpha interferon

Leuk Lymphoma. 1995 Nov;19(5-6):515-7. doi: 10.3109/10428199509112214.

Abstract

A patient treated by recombinant human alpha interferon for chronic myeloid leukemia developed a T cell lymphoma. The T cell lymphoma cells were demonstrated to be genotypically different from the chronic myeloid leukemia cells. The possible role of interferon therapy in stimulating T cell proliferation is discussed.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Hemolytic, Autoimmune / chemically induced
  • Anemia, Hemolytic, Autoimmune / drug therapy
  • Antibiotics, Antineoplastic / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow Transplantation
  • Combined Modality Therapy
  • Humans
  • Hydroxyurea / therapeutic use
  • Immunologic Factors / adverse effects*
  • Immunophenotyping
  • Interferon-alpha / adverse effects*
  • Interferon-alpha / therapeutic use
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
  • Lymphoma, T-Cell, Peripheral / chemically induced*
  • Lymphoma, T-Cell, Peripheral / pathology
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / chemically induced*
  • Prednisolone / therapeutic use
  • T-Lymphocytes / drug effects*

Substances

  • Antibiotics, Antineoplastic
  • Immunologic Factors
  • Interferon-alpha
  • Prednisolone
  • Hydroxyurea