Abstract
The recently published solution structure of the DNA-binding domain of hSRY in complex with a DNA octamer offers insight into the sex reversal effects of mutations in hSRY and the interaction of all HMG boxes with DNA.
MeSH terms
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Binding Sites
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Crystallography, X-Ray
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DNA-Binding Proteins / chemistry*
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High Mobility Group Proteins / chemistry*
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Humans
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Male
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Models, Molecular
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Nuclear Proteins*
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Prejudice
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Protein Structure, Secondary*
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Sex-Determining Region Y Protein
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Transcription Factors / chemistry*
Substances
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DNA-Binding Proteins
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High Mobility Group Proteins
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Nuclear Proteins
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Sex-Determining Region Y Protein
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Transcription Factors