The Osaka University Hospital has developed a totally integrated hospital information system (HUMANE), which features MMML, POE, and PC-based PACS. In order to utilize a PACS in clinical setting, we have developed a delivery and storage system for CR (computer radiography) images in the radiology information system (RIS) and the hospital information system (HIS). As the CR images are displayed on a CRT of a micro frame (personal computer), the system is called as "PC-PACS." Owing to the system, we are able to solve the cost/performance problem and to integrate reports, related schema, and CR images for assistance in decision making at an out-patient clinic. The purpose of this paper is to elucidate the HIS, RIS, and PACS coupling that is very unique in Japan.