Expression of c-fos protein in substance P receptor-like immunoreactive neurons in response to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord segments of the rat

Y Lü; S X Jin; T L Xu; B Z Qin; J S Li; Y Q Ding; R Shigemoto; N Mizuno

doi:10.1016/0304-3940(95)11991-5

Expression of c-fos protein in substance P receptor-like immunoreactive neurons in response to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord segments of the rat

Neurosci Lett. 1995 Sep 29;198(2):139-42. doi: 10.1016/0304-3940(95)11991-5.

Authors

Y Lü¹, S X Jin, T L Xu, B Z Qin, J S Li, Y Q Ding, R Shigemoto, N Mizuno

Affiliation

¹ Department of Anatomy, Fourth Military Medical University, Xi'an, People's Republic of China.

PMID: 8592640
DOI: 10.1016/0304-3940(95)11991-5

Abstract

Chemical irritation of the urinary bladder with formalin in the rat induced c-fos protein-like immunoreactivity in more than 80% of substance P receptor-like immunoreactive (SPR-LI) neurons of the dorsal commissural nucleus, sacral parasympathetic nucleus and lamina I in the 6th lumbar and 1st sacral cord segments. These neurons with SPR-LI may receive noxious information from the urinary bladder through the primary afferent fibers with substance P.

MeSH terms

Animals
Female
Formaldehyde / pharmacology
Immunohistochemistry
In Vitro Techniques
Irritants / pharmacology
Neurons / metabolism*
Proto-Oncogene Proteins c-fos / biosynthesis*
Rats
Rats, Sprague-Dawley
Receptors, Neurokinin-1 / metabolism*
Spinal Cord / cytology
Spinal Cord / physiology*
Stimulation, Chemical
Urinary Bladder / innervation*
Urinary Bladder / metabolism

Substances

Irritants
Proto-Oncogene Proteins c-fos
Receptors, Neurokinin-1
Formaldehyde