The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11

Genomics. 1995 Nov 1;30(1):115-7. doi: 10.1006/geno.1995.0022.

Abstract

The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor, HMMR (human) and Hmmr (mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid analyses. Investigation of two interspecific backcrosses localized the mouse RHAMM (Hmmr) locus 18 cM from the centromere of mouse chromosome 11 within a region of synteny homology with human chromosome 5q23-q35 genes. The map position of the human RHAMM gene places it in a region comparatively rich in disease-associated genes, including those for low-frequency hearing loss, dominant limb-girdle muscular dystrophy, diastrophic dysplasia, Treacher Collins syndrome, and myeloid disorders associated with the 5q- syndrome. The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Carcinoma / genetics
  • Carcinoma / pathology
  • Centromere
  • Chromosome Mapping
  • Chromosomes, Human, Pair 5*
  • Crosses, Genetic
  • Genetic Markers
  • Haplotypes
  • Humans
  • Hyaluronan Receptors / genetics*
  • Hybrid Cells / radiation effects
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Tumor Cells, Cultured

Substances

  • Genetic Markers
  • Hyaluronan Receptors