Abstract
In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a molecule previously implicated in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin repeats, suggests a mechanism for this interaction. It is proposed that Dishevelled, in addition to transducing the Wingless signal, blocks Notch signaling directly, thus providing a molecular mechanism for the inhibitory cross talk observed between these pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Comment
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Clone Cells
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Dishevelled Proteins
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Drosophila / genetics
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Drosophila / growth & development
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Drosophila / metabolism*
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Drosophila Proteins*
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Genes, Insect
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins / antagonists & inhibitors
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Molecular Sequence Data
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Mutation
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Phenotype
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Phosphoproteins*
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Proteins / genetics
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Proteins / metabolism*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism*
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Pupa / metabolism
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Receptors, Notch
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Signal Transduction*
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Wings, Animal / cytology
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Wings, Animal / growth & development
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Wnt1 Protein
Substances
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Adaptor Proteins, Signal Transducing
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Dishevelled Proteins
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Drosophila Proteins
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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N protein, Drosophila
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Phosphoproteins
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Proteins
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Proto-Oncogene Proteins
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Receptors, Notch
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Wnt1 Protein
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delta protein
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dsh protein, Drosophila
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wg protein, Drosophila