Abstract
Novel antioxidants, N-(2-Hydroxy-1-naphthal)amino acids which mimic iron proteins, have been intensively studied for suppressive effect on iron-catalyzed free radical generation. These compounds exhibit inhibition of the Fenton reaction in electron spin resonance assessment. In addition, it is shown that the compounds inhibit iron-induced peroxidation by thiobarbituric acid test. Since these antioxidants form stable complexes with Fe3+, this antioxidative activity is expected to be derived from sequestration of catalytic iron.
MeSH terms
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Binding Sites
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Free Radicals / chemistry
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In Vitro Techniques
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Iron / chemistry*
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Lipid Peroxidation / drug effects
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Models, Chemical
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Organometallic Compounds / chemistry
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Oxidative Stress
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Protein Binding
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Proteins / chemistry*
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Proteins / pharmacology
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Reactive Oxygen Species / chemistry*
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Tyrosine / analogs & derivatives
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Tyrosine / chemistry
Substances
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Antioxidants
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Free Radicals
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Organometallic Compounds
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Proteins
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Reactive Oxygen Species
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iron-tyrosinate complex
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Tyrosine
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Iron