Ozone induction of cytokine-induced neutrophil chemoattractant (CINC) and nuclear factor-kappa b in rat lung: inhibition by corticosteroids

FEBS Lett. 1996 Feb 5;379(3):265-8. doi: 10.1016/0014-5793(95)01524-8.

Abstract

We determined in rat lung whether ozone exposure was associated with the expression of the chemokine, cytokine-induced neutrophil chemoattractant (CINC), and of the transcription factor, NF-kappa B. CINC mRNA expression peaked at 2 h after cessation of ozone exposure, and returned to basal levels by 24 h. DNA-binding activity of NF-kappa B showed a marked increase after ozone, maximal at 2 h. Dexamethasone inhibited CINC mRNA and NF-kappa B expression, together with neutrophilic inflammation. Our data supports the concept that ozone leads to NF-kappa B activation which increases CINC mRNA expression. These series of events could lead to neutrophilic inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Base Sequence
  • Chemokines / metabolism*
  • Chemokines, CXC*
  • Chemotactic Factors / chemistry
  • Chemotactic Factors / metabolism*
  • Dexamethasone / pharmacology*
  • Growth Inhibitors / chemistry
  • Growth Inhibitors / metabolism*
  • Growth Substances / chemistry
  • Growth Substances / metabolism*
  • Inflammation
  • Intercellular Signaling Peptides and Proteins*
  • Lung / metabolism*
  • Molecular Sequence Data
  • NF-kappa B / metabolism*
  • Ozone / antagonists & inhibitors*
  • Ozone / pharmacology
  • RNA, Messenger / analysis
  • Rats
  • Rats, Inbred BN
  • Specific Pathogen-Free Organisms

Substances

  • Anti-Inflammatory Agents
  • Chemokines
  • Chemokines, CXC
  • Chemotactic Factors
  • Growth Inhibitors
  • Growth Substances
  • Intercellular Signaling Peptides and Proteins
  • NF-kappa B
  • RNA, Messenger
  • Ozone
  • Dexamethasone